Description
Indications:
Pregabalin is commonly marketed as ‘Lyrica’. It is used for the treatment of pain of nervous origin like that caused by diabetes mellitus, herpes zoster infection (shingles), spinal cord injury, partial seizures, anxiety, and fibromyalgia.
Mechanism of Action:
Pregabalin binds to α2δ subunit of voltage gated calcium channel of P/Q type. This closes calcium channels and thereby reduce the release of neurotransmitters across the synaptic membrane. This process occurs predominantly in the cortex, olfactory bulb, hypothalamus, hippocampus, amygdala, cerebellum, and dorsal column of spinal cord.
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